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For example, a safety study on green tea polyphenols in middle-aged ovariectomized rats showed that daily administration at levels up to 1.5% (w/w) in drinking water (approximately 633 mg/kg body weight/day) for six months was safe without signs of toxicity 65

-Oxidation of Fatty Acids in Mitochondria The main pathway for the degradation of fatty acids is mitochondrial -oxidation with acetyl-CoA as the end-product, a key metabolic means for energy homoeostasis in issues such as the liver, heart and skeletal muscle

Identifying the key molecular determinants that regulate transcription from 15mer AREs, or others, will be critical to such approaches

FAQs references NIH Office of Dietary Supplements