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CoQ is a central component in the mitochondrial electron transport chain (ETC) located in the inner mitochondrial membrane where it transports electrons from complexes I and II to complex III to provide energy for proton translocation to the intermembrane space (Lpez-Lluch et al., 2 -coupled electron transport (Lapuente-Brun et al., 2 ) directs complex I-specific ROS production to extend lifespan in Drosophila (Scialo et al., 2 levels (Alcazar-Fabra et al., 1A)

APOA5 is associated with TRLs and enhances TG hydrolysis and remnant lipoprotein clearance [82,83]

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The mechanisms underlying CSD involve an imbalance in the brains ionic homeostasis and disruptions in energy metabolism

It is proposed that this disturbance in carnitine homeostasis is reflective of a reduction in carnitine palmitoyltransferase-I (CPT-I) activity, possibly a result of the accumulation of omega-6 fatty acids previously observed in this patient population