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Description
Their activation near the blood-brain barrier, in the perivascular space, can increase vascular permeability and prime microglia, the resident immune cells of the central nervous system 21
120 KitzmillerJ
Donna Felsenstein helped review the manuscript
CuerdaCPironiLArendsJBozzettiFGillandersLJeppesenPBet al
The term tachyphylaxis refers to the decreased responsiveness of a cell to repeated stimulation with drug, and can be due to both processes of GPCR-transducer uncoupling (acute or short-term desensitization) and GPCR downregulation (long-term desensitization) (Figure 1)
