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The importance of Fc-dependent antibody effector functions for protection against yellow fever virus in mice was indicated by the greater efficacy of an IgG2a antibody (which is a potent activator of effector functions) than an IgG1 antibody (a poor activator of effector functions) with the same Fab region 166

The present invention also encompasses polynucleotides encoding mature forms of the present invention, such as, for example the polynucleotide sequence of SEQ ID NO:1, and/or the polynucleotide sequence provided in a cDNA of the deposited clone

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Song C, Shen M, Rodrigues J, Mignani S, Majoral J-P, Shi X

New perspectives of nuclear receptor studies