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Only with the recent development of locus-targeted tools, such as clustered regularly interspaced short palindromic repeats (CRISPR-Cas9) or transcription activator-like effector nucleases-based epigenetic editors, has it become feasible to directly test how defined chromatin or methylation changes influence neural and behavioral outcomes 9,183,184

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This dual improvement in glucose and lipid homeostasis suggests potential applications in research focusing on insulin sensitivity and fatty liver prevention

3.2 Ferroptosis and IBD in the intestinal epithelium The intestinal epithelium is the first line of defense for the intestinal mucosa