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When to reduce the dose Dose reduction is not failure

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In addition to antioxidant regulation, SLC7A11-mediated cystine transport also affects cellular bioenergetics, though with contrasting outcomes: inhibition of xCT promotes mitochondrial metabolism in CD44v high head and neck squamous cell carcinoma (HNSCC) [20], while reduced OCR is observed upon SLC7A11 inactivation in KRAS-mutant lung cancer [21]

Acknowledgements The authors are highly obliged to the Library Department, University of Veterinary and Animal Sciences (UVAS), Government College University Faisalabad (GCUF), and IT Department, Higher Education Commission (HEC, Islamabad) for access to journals, books and valuable database