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Previous animal studies have revealed that noise exposure can induce immediate and permanent cochlear synaptopathy 18 , as evidenced by the fact that synaptic counts measured at 0 h post-exposure are similar to those seen at 24 h, 1 wk and 8 wks thereafter 16

Oxidative stress is continually produced and continually present in the human body

Plasma vitamin B 12 and plasma folate concentrations will be estimated by microbiological assays using a chloramphenicol-resistant strain of Lactobacillus casei and colistin sulfate-resistant strain of Lactobacillus leichmannii , respectively

Moreover, genetic investigations have failed to yield a single therapy to treat the core symptoms

Most patients dont require any topical anesthesia, though it can be used if requested