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To avoid these undesired cellular destructions, organisms have evolved the glutathione-dependent glyoxalase pathway 3 and NAD(P)H-dependent Aldo-Keto reductase pathway 11

37 This regeneration of GSH from GSSG is one of the roles of melatonin in reducing or preventing free radical damage

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Silenced genes with aberrant methylation occurred in almost every significant molecular pathway associated with systemic chemotherapy, such as cell cycle regulation, cell apoptotic, DNA damage repair, cell adhesion and immune response regulation pathways [22]