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Statistically, in healthy individuals, about 12 h after ED ingestion, there is an increase in systolic blood pressure by 610 mmHg, diastolic blood pressure by 36 mmHg, heart rate by about 37 beats/minute, and QT interval prolongation up to 2225 ms

In addition, alcohol is metabolized by alcohol dehydrogenase and cytochrome P450-2E1 (ADH and CYP2E1) enzymes found in the brain endothelial cells leading to the production of ROS, which is responsible for oxidative stress and production of neurodegenerative agents (2)

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The suppressive effects of FUS on G 4 C 2 repeat-induced toxicity was confirmed using multiple FUS fly lines, showing the significant suppression of decreased eye size and loss of pigmentation in ( G 4 C 2 ) 42 or 89 flies coexpressing FUS (Figure 1figure supplement 2)