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It should be noted that while an increase in the androgen receptor and testosterone are pro-androgenic, an increase in SHBG is anti-androgenic, and the researchers took a measurement called the free androgen index (FAI), to assess whether a net positive or a net negative result occurred
Many men on TRT have dramatically reduced or absent sperm counts
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Ferraro PM, Taylor EN, Gambaro G, Curhan GC
J Chromatogr B, 2003;792(1):7382
