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Rajagopal S, Rajagopal K, Lefkowitz RJ (2010) Teaching old receptors new tricks: biasing seven-transmembrane receptors

Cochrane Handbook for Systematic Reviews of Interventions version 6.2

Given the described D1R-GHSR1a dimer, one could propose that GHSR antagonism reduces the reinforcing effects of drugs of abuse like alcohol, nicotine, and cocaine by reducing D1 receptor signaling produced by the D1R-GHSR1a dimer

In some animal experiments, long-term intake of tea catechins may help to suppress obesity by regulating metabolism of lipids, thereby improving lipid and glucose metabolism disorders caused by T2D [74]

This regulation is released by knocking out hemX (Yang et al