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Following administration of phenobarbital via drinking water to F344 rats for three weeks, increased liver weight was found to be a result of hepatocellular hypertrophy, hyperplasia, and enlargement of the hepatic blood space (Massey and Butler 1979)
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Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Huser W, Katz RL, et al
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Stephens, N
