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Gap junction conductance is one of the systems in the lens that could be affected, since gap junction permeability is generally decreased at low pH
doi: 10.4161/oxim.1.1.6481
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The E3 ubiquitin ligase Trim31 is involved in cerebral ischemic injury by promoting degradation of Tigar
They tend to show up as a general daily drag: things that are easy to attribute to stress, aging, or just a rough stretch
