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The authors would like to thank Vaishali Chudasama for early support of the AMG 966 clinical development program, Darren Bates and Zhulun Wang for assistance with reagents for in vitro T cell assays, Qingchun Zhang, Nic Angell and Greg Barnett for assistance with SEC-MALS experiments, Fanching Lin for technical assistance with the TL1A assay, Richard Hu for assistance with biomarker analysis, and Shalini Gupta and Marta Starcevic-Manning for support of immunoassay and domain characterization experiments

Zinc, selenium and reduced glutathione are powerful antioxidants and vitamin B6 and molybdenum aid sulphur amino acid metabolism, supporting detoxification

For example, mitochondrial dysfunction destabilizes lysosomes, amplifying oxidative stress (57)

However, even though dietary interventions, such as CR, have been shown to impact on lifespan, the causal evidence that establishes histone modifications as the molecular bridge between diet and longevity is still underdeveloped