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Penetration of stroma-rich 3D PDAC spheroids The desmoplastic ECM acts as a pathological barrier which impedes drug diffusion and penetration into PDAC tissue

However, this finding may be limited to the specific mouse model, given the fundamental functions of P40 and CD25 in immune tolerance

Parental folate deficiency inhibits proliferation and increases apoptosis of neural stem cells in rat offspring: aggravating telomere attrition as a potential mechanism

The use of non-site-specific coupling techniques can alleviate the complexity inherent in antibody-specific site mutations, simplifying the optimization process