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Hypervolemic can occur for three reasons: i) Hyperglycemia causes extracellular compartment expansion as water is pulled from the intracellular space ii) The tonicity of the serum glucose causes profound thirst, which can lead to drastically increased oral intake (given thirst is usually considered suggestive of hypovolaemia, it is worth noting that this history finding is unhelpful in this exceptional setting) iii) Volume overload at baseline / missed dialysis sessions, etc

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USP 797/800 Sterile Compounding Standards: Confirmed environmental monitoring, clean-room classification, and aseptic technique validation

Latts LM et al
