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Drucker cautions that many of the peptides promoted online do not have a large body of medical evidence showing their safety and effectiveness the way GLP-1s do

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The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference

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