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Expected timeline: Appetite suppression from tirzepatide begins within the first two weeks

At 0.5mm, a stamped microneedle traverses the stratum corneum (typically 10 to 30 microns), passes through the viable epidermis (50 to 100 microns), and lands in the upper papillary dermis (which begins around 100 to 150 microns deep)

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Timing Optional Monitoring guidance is label-informed for tirzepatide and supported by incretin-class clinical monitoring considerations