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The number of intensive care unit hospitalizations due to CAP have been rising steadily in recent years, especially in the older population, where CAP is a common cause of hospitalization, readmission, and death ( Streptococcus pneumoniae remains a major pathogen for all ages worldwide ( Additionally, the aging process is accompanied by chronic inflammation and immune senescence ( acute respiratory distress syndrome (ARDS) and acute lung injury have been clinically demonstrated