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Description
Over the years, limited published clinical trials using a relatively small number of study subjects have demonstrated melatonins role in rebalancing bone remodeling in perimenopausal women [196] and increasing bone density in postmenopausal women with osteopenia [197]

Estrogen and progesterone levels are at their lowest , and the hypothalamus responds by increasing secretion of gonadotropin releasing hormone (GnRH), which triggers pituitary production of gonadotropinsfollicle stimulating hormone (FSH) and luteinizing hormone (LH)

Staff et al

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(3) Bellei B, Papaccio F, Picardo M