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Genetics of Pancreatic -Cell Function and Insulin Secretion As discussed in the following sections, there are numerous metabolic processes and metabolites that serve to regulate pancreatic -cell insulin secretion, with glucose metabolism being the most significant

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Chronically elevated fasting blood glucose levelsor recurrent, excessive spikes in glucose levels after mealscan lead to devastating long-term consequences such as heart disease, blindness, kidney failure, liver disease, and cancer