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In humans, hyperhomocysteine is related to cobalamin deficiency [52], whereas in dogs, homocysteine can be used mainly in the diagnosis of familiar cobalamin deficiency specifically in the Chinese Shar-Pei [53], but only after other diseases have been ruled out [54]

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Addressing Environmental Factors Holistic treatment extends beyond individual health strategies to encompass environmental considerations

244 In diabetic complications research, the activation of p53/SLC7A11/GSH axis causes endothelial cell ferroptosis under hyperglycemia, suggesting the important role of ferroptosis of endothelial dysfunction caused by diabetes