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Overall, natural compounds show minimal systemic or organ toxicity at therapeutic doses, although mild side effects may occurcurcumin, for instance, has resulted in only minor gastrointestinal upset even at high doses [22, 30, 57]

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In that situation, portal insulin levels are generally high due to insulin resistance [16,17]

This manipulation produced a risk-avoidance phenotype in mice and promoted alcohol anxiolytic effects, from the very first exposure to alcohol, suggesting these behaviors are the consequence of a preexisting imbalance in striatal dopamine receptor levels