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Secretion of IFN, IL-17, and IL-22 by Th1 and Th17 cells activates B cells, which secrete anti-tTG, anti-neo-tTG, and anti-endomysial autoantibodies (EMA)

The authors will supply the relevant data in response to reasonable request

10.1016/j.cell.2012.03.042 6 GaoM.YiJ.ZhuJ.MinikesA

Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)