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Use raw HR for this calculation, not placebo-subtracted (placebo arm shows real cardiovascular adaptation from weight loss + lifestyle counseling, so subtraction over-corrects for drug-attributable cost)

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Molecules, 30 (18), Article 3683
Excessive secretion of zonulin causes prolongation of the opening time of TJ, which can prolong the abnormal activation of the immune system over time [16, 18, 70,71,72]