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The dose needed depends on how severe the deficiency is and the persons health

(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)

These include Crohn's disease affecting the terminal ileum, coeliac disease, previous gastric or ileal surgery, and pancreatic insufficiency

For individuals who have problems with absorbing the vitamin, suffering from mild deficiency, pregnant women, a 1000 mcg dose is best

Antacids may decrease the absorption of steroids and this may require dose adjustment, especially in patients receiving low doses