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In orthotopic and postsurgical TNBC mouse models, MND-ART-GEL significantly inhibited tumor growth and recurrence, remodeled the immunosuppressive tumor microenvironment, enhanced CD8+ T-cell infiltration, dendritic cell maturation, and M1 macrophage polarization, reduced PD-1/PD-L1 expression on CD8+ T cells, and promoted the secretion of immune-related cytokines

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Here, the authors 2 find elevated expression of ACTL6A in gastric cancer promotes glutathione synthesis by regulating 3 GCLC expression to suppress ferroptosis.

Pulmonary hypertension (PH) is a global health issue characterized by high mortality

The GLS2 structures reveal that the activation loop, a motif previously identified to regulate enzymatic activity, assumes a unique conformation and works together with a lid that closes over the active site to lock in the substrate glutamine