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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Ronnett GV, Kleman AM, Kim EK, Landree LE, Tu Y

Vitamin B12 treatment increases serum B12 concentrations and decreases methylmalonic acid and homocysteine levels [18], but the normalization of these markers does not always correspond to clinical improvement

The best time of day to ingest this treatment is in the morning

[15] The intramuscular route bypasses the digestive system, allowing the nutrients to be absorbed directly

Our team has observed that for studies focusing on long-term, sustained NNMT inhibition where slight variations in peak plasma concentration aren't catastrophic, the oral route might be sufficient