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Cell-based phenotypic screening is more efficient for identifying lead compounds that are physiologically and disease-relevant for drug development

Physiol Plant 106:1727 Pemble SE, Taylor JB (1992) An evolutionary perspective on glutathione transferases is inferred from class-theta glutathione transferase cDNA sequences

One-Carbon Metabolism Biomarkers and Cognitive Decline in the Very Old: The Newcastle 85+ Study

Rodents infused with angiotensin II had greater gut permeability as assessed by FITC-Dextran [92, 48] and decreased intestinal gene expression of tight junction proteins including ZO-1, particularly on a low fibre diet [48, 96], which was accompanied by increased intestinal expression of the inflammatory cytokines TNF- and IL-6 [96]

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