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Interestingly, these hub regions which process large amounts of information have high metabolic requirements, are characterized by the co-expression of genes regulating oxidative metabolism, and might be particularly sensitive to OxS [161]

Notably, tight junction-to-cytoplasm switching of ZO-1 was found to occur in an energy-dependent manner, which required activity of the actin-binding region (ABR) and MLCK

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Prior to extubation, consider chest physiotherapy, lung recruitment maneuvers, and endotracheal suction to mobilize secretions and prevent atelectasis

Critically, the primary pain outcome did not improve significantly in the probiotic groupa negative result that warrants explicit emphasis, as it runs counter to the hypothesis that probiotics can reduce FM-related pain