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Systemic effects of long-term, higher-dose ICS: Adrenal suppression Decreased bone mineral density Increased risk of cataracts and glaucoma Oral corticosteroid systemic effects (more severe, especially with prolonged use): Osteoporosis, diabetes, hypertension, weight gain, mood changes Drug Interactions Theophylline is metabolized by the cytochrome P450 system (primarily CYP1A2), making it susceptible to many interactions: Ciprofloxacin inhibits CYP1A2 increases theophylline levels (toxicity risk) Rifampin induces CYP enzymes decreases theophylline levels (reduced efficacy) Beta-2 agonists and beta-blockers work in direct opposition

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Genome-wide identification of MGT gene family in soybean ( Glycine max ) and their expression analyses under magnesium stress conditions

However, redox signaling leads to the increased activity of IB kinase (IKK), which phosphorylates and targets IB for degradation

doi: 10.1089/thy.2004.14.1077 83 EmderPJJackMM