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This was later detected on the cell surface upon analyzing the translational product of 21-exon MET proto-oncogene and was classified as a growth factor receptor of the tyrosine kinase family

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conversely, insulin can bind IGF1R with lower affinity than it has for the insulin receptor IGF1R and the insulin receptor can form heterodimers that bind both ligands IGF1 has actions distinct from those of growth hormone in carbohydrate, lipid and protein metabolism

COMT enzymes are also involved in metabolizing the female hormone estrogen and any gene alteration may cause estrogen dominance