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This can occur due to loss of appetite, digestive issues, and muscle weakness, which are common side effects of B12 deficiency

doi: 10.1186/s40168-017-0373-4 71 NevelingD

In addition, differentially expressed genes in the ovary of a shrimp fed with a krill oil diet were enriched in metabolism of xenobiotics by cytochrome P450 ( CYP450 ). Aromatase is CYP450(19) , the rate-limiting enzyme in estrogen biosynthesis, through interaction with NADPH-cytochrome P450 reductase (CPR) and catalyzes a three-step hydroxylation to convert androgens (androstenedione and testosterone) to estrogen (estrone and estradiol) (59)

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metabolic causes such as liver failure or kidney failure