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This could be traced back to the fact that GSTO1 is not under Nrf2/ARE control [271]: it acts more like glutaredoxins than GSTs [272] and is involved in the activation of inflammasome [273]

Create functional folate deficiency (a buildup of inactive folate that can't do its job), because B12 is a cofactor for the enzyme that turns inactive folate into active folate

First, the current body of evidence lacks large-scale, long-term randomized controlled trials (RCTs) evaluating the sustained effects of specific diets and herbal supplements in diverse populations

Despite this high heterogeneity, the notable improvement in MGYSS suggests that the thermal pulsation system effectively enhances meibomian gland function, which is essential for addressing dry eye symptoms and improving overall ocular surface health

[DOI] [Google Scholar] 195.Paz R.D., Landzuri A.C., Vernaza M.G