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But the primary concern is the risk of ochronosis, a rare but challenging condition where long-term overuse paradoxically causes darkening of the skin, says Francesa Lewis, MD, a board-certified dermatologist in Delray Beach, Florida

However, because it is so active in the body, it gets used up quickly

Athira Pharma (formerly M3 Biotechnology), the WSU spinout founded to commercialize Dihexa-derivative compounds, paid approximately $4 million in a False Claims Act settlement in January 2025 after a whistleblower exposed concealment of the research misconduct from federal grant agencies, and approximately $10 million in a separate class-action settlement to investors

29 , liver C57BL/6 data obtained from Xiao et al

Apr 28th, 2026 How TB-500 Promotes Recovery and Angiogenesis TB-500 is a synthetic fragment of thymosin beta-4 associated with tissue repair and angiogenesis, but human evidence is limited, it is not FDA-approved, and its safety and effectiveness remain uncertain