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Previous transcriptomic work in ROSMAP samples has associated the retention of excitatory IT neurons with better residual cognition 20

Wistar rats (170200 g), male, albino, four- to six week-old

10.3748/wjg.v20.i25.8082 56

doi: 10.1016/j.jconrel.2021.07.048

BHB acts as a ligand for the cell surface G-protein-coupled receptor, hydroxycarboxylic acid receptor 2, also called GPR109A, which polarizes macrophages and other immune cells into an anti-inflammatory phenotype 18
