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However, enhanced ROS production as a result of the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributes significantly to the pathogeneses of vascular diseases
The lid-loop spanning segment from Pro438 to Gly449 in EcGGT contains an aromatic residue tyrosine (Try444), which has been reported to form a hydrogen bond with conserved residue Asn411 by its side chain hydroxyl group (Figure 6)
By reducing the activity of the enzyme tyrosinase, glutathione helps decrease melanin production
Chen D, Fan Z, Rauh M, Buchfelder M, Eyupoglu IY, Savaskan N
M.LacanS.DicarloC
