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Negative outcomes for mothers or babies can occur as a result of complications or issues during pregnancy, birthor the post-partum period
Validating these findings, we show that deletion of the mitochondrial pyruvate carrier, which is known to decrease TCA cycle activity and protect the liver from diet-induced injury, also diminished NADPH, elevated glutathione oxidation, and alleviated ER stress
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Accordingly, agents that restore glutathione-glutamate homeostasis may afford therapeutic benefit.
Oxidative damage to the heart often leads to heart disease like stroke, heart attacks, and other life-threatening conditions
