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Oxidatively modified Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer disease: many pathways to Neurodegeneration

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Thus G6PD deficiency increases the sensitivity of the myocardium for ROS and exacerbates contractile dysfunction in the face of oxidative injury

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LPS can activate the TLR4 signaling pathway, leading to nuclear factor kappa B (NF-B) intracellular signal transduction and the production of inflammatory cytokines such as tumor necrosis factor (TNF)-, IL-6, and IL-1 [17]