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Description
The cytoprotective (reduced reactive oxygen species and reduced cell senescence) effects of ergothioneine on endothelial cells exposed to hyperglycaemic conditions have been shown to be dependent on sirtuin 1 and sirtuin 6 activities and their cellular targets (89) , which notably include NF- B, the aforementioned transcriptional regulator of SLC22A4 (63)
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Friden M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M
doi: 10.1093/stcltm/szac004 84 XiaoXXuMYuHWangLLiXRakJet al
10.1016/j.molmed.2019.11.005 142
