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Tissue injury was evaluated microscopically by a blinded examiner using an Olympus BX51 microscope and Olympus 71 digital camera, saving images as uncompressed 24-bit RGB TIFF files

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In primary SS renal tubulointerstitial injury, CD163-positive cells and high expression of HIF-1 were reported, where HIF-1 could promote macrophage polarization and participate in renal tubular injury, and early intervention to release HIF-1 could improve renal function in patients (197)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Freudenheim J.L., Graham S., Marshall J.R., Haughey B.P., Cholewinski S., Wilkinson G