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In addition, ferroptosis, as a form of inflammatory cell death, is associated with the release of DAMPs, which can trigger the innate immune system and activate the NF-B pathway through AGER [95, 109]

Sustained GF/cytokine activity combined with an aberrant/excessive interstitial cell stimulation arguably constitutes a self-enhancing loop that promotes tubular injury and TIF

Zhao H, Li R, Chen Y, Yang X, Shang Z (2023) Stromal nicotinamide N -methyltransferase orchestrates the crosstalk between fibroblasts and tumour cells in oral squamous cell carcinoma: evidence from patient-derived assembled organoids

Despite its lower BBB penetration compared to DFP, DFO can reduce iron accumulation in the SN, protect dopaminergic neurons, and alleviate motor dysfunction (198)