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Extracellular mtDNA could engage pattern recognition receptors (PRR) on microglia, astrocytes, and infiltrating immune cells, serving as a potent pro-inflammatory signal that drives neuroinflammation in acute brain injury, ischemia, and chronic NDDs

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References 1 Avsian-KretchmerO.EshdatY.Gueta-DahanY.Ben-HayyimG

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