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Materials and methods Study participants The study was approved by the Research Ethics Board, McMaster University (Institutional Review Board no

Tendon and Ligament Repair Moderate to Strong Evidence Evidence Rating: Moderate-Strong (Several animal studies, some independent replication) Research support for musculoskeletal healing is substantial: Achilles tendon injuries Ligament damage (MCL, ACL) Rotator cuff healing General tendinopathy Surgical repair enhancement The FAK-paxillin mechanism and VEGF upregulation provide clear biological rationale for these effects

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Carefully adjust dose for patients on anticoagulant therapy under cardiological/hematological management

Saper stresses that given the severe joint destruction rheumatoid arthritis can cause, conventional therapy should always be the mainstay of treatment