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In addition, the financial burden of chronic pain in the United States is estimated to be as high as $635 billion a year, which is more than the annual cost for cancer and heart disease combined.[30] NP is a collection of pain disorders resulting from damage to the somatosensory nervous system [31], characterized by disease or lesions on the neurons that can occur peripherally (e.g., chemotherapy-, diabetic- or postherpetic-induced neuralgias) or centrally (e.g., spinal cord injury (SCI) or post-stroke pain) [32]

When taken together, they may have an additive effect that requires careful observation and professional guidance

First-in-man controlled rewarming and normothermic perfusion with cell-free solution of a kidney prior to transplantation

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