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Oxidative phosphorylation is a metabolic vulnerability in PDX models with primary and secondary resistance to the CDK4/6 inhibitor palbociclib CDK4/6 inhibitors have been approved as first-line treatment for advanced BC patients in combination with aromatase inhibitors or fulvestrant

Its reproducible behavior across instruments allows laboratories to benchmark new analytical systems

DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines

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