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Pharmacological stabilization of HIF-1 has been shown to induce expression of the vitamin D receptor and antimicrobial peptide hBD-2, while simultaneously reducing the release of TNF- and IL-10, thereby significantly inhibiting bacterial proliferation (Nickel et al., 2012)

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At the end of the study, the authors observed improved dermal density, reduced periorbital wrinkles, and skin smoothness in the treatment group

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To shorten the description, the use of NADPH at several concentrations is not described here, but was performed by the same statistical methods of analysis previously described for GP