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ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways

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From the perspective of this review, however, we think it more likely that any beneficial effects of such inhibition may be mediated via other parts of the tryptophan degradation pathway that are likely to change simultaneously (see Figure 3, and, e.g., [197,198]), and indeed we are not aware of any marketed drug for such disorders based on selective inhibition of KAT II enzymes

doi: 10.1080/00087114.2015.1109954 222 WangH.ChenR