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When Rab27a levels were reduced by knockdown in endothelial cells, DHHC3 overlap with the Golgi marker TGN46 increased and overlap with Rab27a decreased in the absence of reduced DHHC3 levels, consistent with mis-trafficking (Fig

Molecules 24 (5), 955

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In terms of 12-week sustained accumulation of physical disability, there was a statistically significant 31.5% (p=0.0442) reduction for teriflunomide 14 mg, but the reduction was not significant for teriflunomide 7 mg, as compared to placebo
The figure 25.3 % surpasses: Tirzepatide SURMOUNT-1: 22.5 % Semaglutide STEP-1: 14.9 % Retatrutide Phase 2: 24.2 % (comparable, but Phase 3 results for Retatrutide are still lacking) It raises the question whether CagriSema will be the first molecule with an effect truly comparable to bariatric surgery (typically 2530 % reduction)
