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In healthy individuals, LPS remains in the lumen due to proper tight junction seclusion among other barrier functions

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DNMTi and HDACi can reactivate the transcription of these APM genes through demethylation or by promoting histone acetylation, restoring MHC-I expression on the tumor cell surface and enhancing their capacity to present antigens to CD8 + T cells [357]

Some of these alkaloids have been approved by the FDA as chemotherapy drugs, such as camptothecin (CPT), 190 a well-known inhibitor of topoisomerase I, and vinblastine, 191 which interacts with microtubule proteins to cause mitotic disasters

This marks a change from simply treating symptoms